###### Created: 2023-09-08 19:04 ###### Areas & Topics: #medicine #paediatrics ###### Note Type: #permanent ###### Connected to: [[Child Development and Milestones]] - Pierre Robin Sequence (PRS) is a condition characterised by micrognathia (mandibular hypoplasia), glossoptosis (downward displacement of the tongue) and upper airway obstruction. - It is also commonly associated with the presence of cleft palate, although this is not a necessary feature for diagnosis. - A sequence is where one malformation leads to a chain of events that cause other abnormalities, whereas a syndrome is a collection of symptoms which are not caused by one another by arise due to a shared pathogenesis. - This is why PRS was originally known as Pierre Robin Syndrome, but was changed recently. - PRS is associated with a multitude of other syndromes (e.g. stickler syndrome, velocardiofacial syndrome etc.) but the aetiology and pathophysiology of the condition is largely unknown. ![[pierre-robin_syndrome.jpg]] ### Resources https://www.ncbi.nlm.nih.gov/books/NBK562213/